Research progress of glycocalyx on endothelium in sepsis
10.3760/cma.j.issn.2095-428X.2018.18.018
- VernacularTitle:内皮细胞表面糖萼在脓毒症中的研究进展
- Author:
Jiayun YING
1
;
Guoping LU
Author Information
1. 复旦大学附属儿科医院重症医学科
- Keywords:
Glycocalyx;
Sepsis;
Pathophysiology
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(18):1435-1437
- CountryChina
- Language:Chinese
-
Abstract:
The mortality of sepsis remains high,and it is still a major cause of death in critically ill patients.But its pathophysiological mechanism remains a mystery,not yet fully clear.Endothelium play an important role in the development of sepsis.Maintaining the integrity of its surface glycocalyx to a certain extent reduces sepsis damage;and its destruction mediates a series of pathophysiological responses,including increasing vascular permeability by cell pathway or intracellular pathways,increasing the adhesion of white blood cells to endothelial cejls and a variety of cytokines to promote inflammatory response,activating of thrombin to coagulation dysfunction,promoting synthesis of nitric oxide to change vascular tension.The damage of glycocalyx as a first step in endothelial cell injury can be used as early diagnosis and prognosis of sepsis,which provides new ideas for the diagnosis and treatment of sepsis.
