Th17/IL-17 axis and kidney diseases
10.3760/cma.j.issn.2095-428X.2018.17.018
- VernacularTitle:Th17/IL-17轴与肾脏疾病
- Author:
Yajun MAO
1
;
Hongzhu LU
Author Information
1. 长江大学第一临床医学院儿科
- Keywords:
Th17/IL-17 axis;
T helper 17 cells;
Interleukin 17;
Cytokine;
Kidney disease
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(17):1354-1357
- CountryChina
- Language:Chinese
-
Abstract:
Th17 cell is a newly developed CD4 +T cell subsets,play a pro-inflammatory role and participate in the pathogenesis of many autoimmune diseases mainly through secretion of cytokines such as interleukin-17 (IL-17),many of the biological effects of Th17 cells are closely related to the IL-17,this article reviews the relation-ship between Th17/IL-17 axis and related cytokines and kidney the pathogenesis of disease,in order to more in-depth understanding of the pathogenesis of kidney disease,provide the basis for looking for new targets of diagnosis and treatment of kidney disease and new treatment strategies.
