Bartter syndrome and Liddle syndrome
10.3760/cma.j.issn.2095-428X.2018.17.003
- VernacularTitle:Bartter综合征和Liddle综合征
- Author:
Jianhua ZHOU
1
Author Information
1. 华中科技大学同济医学院附属同济医院儿科
- Keywords:
Bartter syndrome;
Liddle syndrome;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(17):1289-1292
- CountryChina
- Language:Chinese
-
Abstract:
Bartter syndrome and Liddie syndrome are genetic renal tubular disorders characterized by hypokalemic alkalosis.Bartter syndrome is mainly an autosomal recessive disease,caused by mutations of one of the five ion channel genes in renal tubular epithelial cells.Plasma renin and aldosterone levels are increased but blood pressure is normal,the main treatment is to correct hypokalemia,to prevent and cure complications.Liddle syndrome is an autosomal dominant disease,caused by epithelial Na-channel gene mutation,and presented with increased blood pressure but decreased plasma levels of renin and aldosterone.Patients with Liddle syndrome should limit the intake of sodium and supplement potassium,take Triamterene or Amiloride to control hypertension.
