Advances on mesenchymal stem cells in the treatment of bronchopulmonary dysplasia

VernacularTitle:间充质干细胞治疗支气管肺发育不良研究进展
Author: Jingyi YOU ¹ ; Chang SHU ; Zhou FU
Author Information

1. 400014,重庆医科大学附属儿童医院呼吸科
Keywords: Mesenchymal stem cell; Cell therapy; Bronchopulmonary dysplasia
From: Chinese Journal of Applied Clinical Pediatrics 2018;33(16):1267-1270
CountryChina
Language:Chinese
Abstract: Bronchopulmonary dysplasia(BPD)is the most common chronic respiratory disease in premature in-fants,there is a lack of effective treatment now. In recent years,animal studies showed that treatment of mesenchymal stem cells (MSCs)can ameliorate hyperoxia-induced lung injury by promoting the restoration of alveolar epithelium and reducing the inflammation of lung through regeneration,paracrine and immunomodulatory,moreover,there has been a clinical trial shows that MSCs in the treatment of BPD is safe and feasible. Which may benefit the recovery of BPD and bring a hope for radical treatment of BPD. Now,focusing on the biological characteristics of MSCs,the mechanism and application of MSCs in the treatment of BPD in animal models and clinical trials as well as the existing problems in the latest research were reviewed.