Research progress on the pathogenesis of competing endogenous RNA in cardiovascular diseases

VernacularTitle:竞争性内源RNA与心血管疾病发病机制的研究进展
Author: Binlu ZHU ¹ ; Hongkun JIANG
Author Information

1. 中国医科大学附属第一医院儿科
Keywords: Competitive endogenous RNA; Cardiovascular diseases; Circular RNA; Long non-coding RNA; miRNA
From: Chinese Journal of Applied Clinical Pediatrics 2018;33(13):1033-1036
CountryChina
Language:Chinese
Abstract: MicroRNA(miRNA)can reduce the stability of the messenger RNA(mRNA)or inhibit the transla-tion of the messenger RNA by targeting its 3'-untranslated region(UTR),thereby negatively regulate the expression of the target gene.Diverse RNA transcripts including mRNAs;pseudogenes;long non-coding RNAs(LncRNA)and circu-lar RNAs(circRNAs)can competitively combine with the same miRNAs by microRNA response elements(MREs),re-moving or reducing the inhibition of genes targedted by the miRNAs and regulating the expression of the target genes. These RNA transcripts are called competitive endogenous RNA (ceRNA),and this new post-transcription regulation model is called ceRNA hypothesis.CeRNA not only participates in the proliferation,differentiation and aging of normal cells,but also plays an important role in the pathogenesis of tumor and cardiovascular diseases(CVD).This paper re-viewed the studies about ceRNA in cardiovascular diseases in recent years.