Research progress on signal pathways relevant to Hirschsprung's disease
10.3760/cma.j.issn.2095-428X.2018.12.022
- VernacularTitle:先天性巨结肠相关信号通路研究进展
- Author:
Lu HUANG
1
;
Yuanmei LIU
Author Information
1. 563003,遵义医学院附属医院小儿普胸泌外科
- Keywords:
Hirschsprung's disease;
Gene mutation;
Signal pathway
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(12):957-959
- CountryChina
- Language:Chinese
-
Abstract:
Hirschsprung's disease(HSCR)is a kind of complex digestive system disease with structural abnor-malities,implicated a genetic,polygenic,multifactorial disease. Etiology and pathogenesis of HSCR are not clear,now re-search shows there is complex,multiple and abnormal signal transduction with development of HSCR. The variable phe-notypic of HSCR may be the result of some gene mutation interfering with ganglion cell migration in signal pathway. Re-cently study has found that there are several signal transduction pathways strongly relevant to HSCR. Now,the research progress in primarily signal pathways relevant to HSCR were reviewed.
