Effect of gene regulation in pathogenesis of biliary atresia

VernacularTitle:基因调控在胆道闭锁发病中的作用
Author: Zhu JIN ¹ ; Yuanmei LIU
Author Information

1. 563003,遵义医学院附属医院小儿普胸泌外科
Keywords: Biliary atresia; Gene; Child
From: Chinese Journal of Applied Clinical Pediatrics 2018;33(11):801-804
CountryChina
Language:Chinese
Abstract: Biliary atresia (BA) is a common neonatal liver disease characterized by inflammation and fibrosis of the extrahepatic biliary ducts,leading to cholestasis and biliary cirrhosis.It is also a severe liver disease in infants.The pathogenesis of BA is associated with multiple genes and gene polymorphism,virus infections,epigenetic,immune abnormalities,and so on.With the development of genetic technology,it provides a new method to determine the susceptibility genes in BA.Now,more and more doctors pay attention to the change and regulation of genes in BA.