Definition and pathogenesis of protracted bacterial bronchitis in children
10.3760/cma.j.issn.2095-428X.2018.10.002
- VernacularTitle:儿童迁延性细菌性支气管炎的定义及发病机制
- Author:
Yuqing WANG
1
;
Chuangli HAO
Author Information
1. 215003,苏州大学附属儿童医院呼吸科
- Keywords:
Protracted bacterial bronchitis;
Chronic cough;
Child;
Bronchoalveolar lavage fluid
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(10):723-727
- CountryChina
- Language:Chinese
-
Abstract:
Protracted bacterial bronchitis (PBB) is a common cause of children with chronic wet cough.Original microbiologic-based case of PBB was defined as wet cough (＞ 4 weeks) without signs of another cause,bacterial pathogens growing and quantitative culture ≥ 107 cfu/L in bronchoalveolar lavage fluid and cough resolved following a 2-week course of an appropriate oral antibiotics (usually amoxicillin-clavulanate).In recent years,clinical-based case definition of PBB,refractory PBB and recurrent PBB have been proposed to increase its clinical applicability.At present,the pathogenesis of PBB including biofilm formation,impaired airway muco-ciliary clearance,neutrophil inflammation,immune dysfunction and inappropriate use of antibiotics.
