Association between miR146a(rs2910164)G>C polymorphism and susceptibility to acute lymphoblastic leuke-mia in children
10.3760/cma.j.issn.2095-428X.2018.03.010
- VernacularTitle:miR146a(rs2910164)G>C多态性与儿童急性淋巴细胞白血病易感性的关系
- Author:
Xiaolei LIU
1
;
Liying LIU
;
Zheli CAO
;
Baozhen GUO
;
Mingwei LI
Author Information
1. 071000,保定市第一中心医院血液内科
- Keywords:
miR146a(rs2910164)G>C polymorphism;
Leukemia,lymphoblastic,acute;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between miR146a(rs2910164)G>C polymorphism and susceptibility to acute lymphoblastic leukemia(ALL)in children.Methods Two hundred blood specimens were ob-tained from children with ALL as patient group and 100 blood specimens were obtained from healthy children as healthy control group,who were all from Baoding First Central Hospital between March 2010 and October 2016.There were no significant differences in sex and age between patient group and healthy control group(χ2=0.430,P=0.512;χ2=2.839,P=0.092).The distribution of gene frequency of patient group and healthy control group conformed to Hardy-Weinberg equilibrium.miR146a(rs2910164)G>C polymorphism was identified by adopting restriction fragment length polymorphism(RFLP).The relation of genotype and ALL was demonstrated by odds ratio(OR)and 95% credibility interval(CI). Results Gene frequency of miR146a(rs2910164)GG,GC and CC genotypes in patient group and healthy control group was 16.0%,44.5%,39.5% and 29.0%,41.0%,30.0%,respectively.The GC/CC genotypes were significantly higher in patient group than those in healthy control group(GG genotype as reference,GC genotype:OR=1.967,95%CI:1.054-3.672,P=0.037;CC genotype:OR=2.386,95%CI:1.239-4.595,P =0.012). Conclusion miR146a(rs2910164)G>C polymorphism is significantly associated with susceptibility to ALL in chil-dren.
