Improving the understanding of pediatric myelodysplastic syndrome
10.3760/cma.j.issn.2095-428X.2018.03.002
- VernacularTitle:加强对小儿骨髓增生异常综合征的认识
- Author:
Juanjuan LI
1
;
Rong LIU
;
Xiaodong SHI
Author Information
1. 100020,首都儿科研究所附属儿童医院血液科
- Keywords:
Myelodysplastic syndromes;
Molecular mechanism;
Clonal evolution;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(3):165-170
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes(MDS)represent a heterogeneous group of myeloid neoplasms initiated from stem cells and/or progenitor cells,which is primarily a disease of elderly.In childhood,MDS is uncommon.As for its mechanism,there has been a considerable improvement,involving cytogenetics,molecular biology.Besides,the rela-tionship between hematological clonal evolution and initiation,development and prognosis of MDS,has also been repor-ted systemically.These mechanisms are summarized and some characteristics of pediatric cases are reviewed.
