Cognitive development of children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study
10.3760/cma.j.issn.2095-428X.2018.02.014
- VernacularTitle:注意缺陷多动障碍患儿认知发展的静息态功能磁共振研究
- Author:
Kaihua JIANG
1
;
Aibin ZHENG
;
Li DING
;
Huijuan SHEN
;
Hongxin LI
;
Jianrong LIU
Author Information
1. 213003,南通大学附属常州市儿童医院儿童健康研究中心
- Keywords:
Attention deficit hyperactivity disorder;
Functional magnetic resonance imaging;
Degree centrality;
Children's cognition
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of cognitive development of children with attention deficit hyperactivity disorder (ADHD) by using resting-state functional magnetic resonance imaging (fMRI) degree centrality (DC) from the view of neuro-imaging.Methods Forty-five ADHD children were diagnosed at specialist clinic of Changzhou Children's Hospital,Nantong University from June 2015 to December 2016,and they were divided into 3 groups according to their ages (children aged 7-8 years old,9-10 years old and 11-12 years old,15 children in each group) and received the resting-state fMRI scans.DC value was used to analyze fMRI data.Comparative analysis was done pairwise between the three groups.Results Compared with 7-8 years old group,9-10 years old group showed lower DC value in cerebellum posterior lobe (t =-4.36) and higher DC in inferior parietal lobe (t =-5.86),and the differences were statistically significant (all P ＜ 0.05,after correction).Compared with 7-8 years old group,11-12 years old group showed lower DC value in cerebellum posterior lobe (t =-4.99) and higher DC in left superior temporal gyrus (t =5.18) and superior frontal gyrus (t =4.58),and the differences were statistically significant (all P ＜ 0.05,after correction).Compared with 9-10 years old group,11-12 years old group showed lower DC value in inferior parietal lobe (t =-5.71) and higher DC value in left superior temporal gyrus (t =5.05) and superior frontal gyrus (t =4.36),and all the differences were statistically significant (all P ＜ 0.05,after correction).Conclusion Children with ADHD at different ages had different characteristics of brain regions of fMRI.It can offer objective evidence for early cognitive intervention of children with ADHD at different ages.
