Association of biliverdin reductase A gene polymorphisms with neonatal hyperbilirubinemia from Fujian area
10.3760/cma.j.issn.2095-428X.2018.02.007
- VernacularTitle:胆绿素还原酶A基因多态性与福建地区新生儿高胆红素血症的相关性
- Author:
Jinfu ZHOU
1
;
Changyi YANG
;
Shuwei CHEN
;
Yinglin ZENG
;
Jing WANG
;
Hong ZHAO
;
Yao CHEN
;
Feng LIN
;
Dan LIN
;
Wenbin ZHU
Author Information
1. 350001 福州,福建省妇幼保健院,福建医科大学附属医院新生儿疾病筛查中心
- Keywords:
Hyperbilirubinemia;
Infant,newborn;
Biliverdin reductase A gene;
Single nucleotide polymorphism
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(2):108-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association of single nucleotide polymorphisms (SNPs)of biliverdin reductase A (BLVRA) with neonatal hyperbilirubinemia from Fujian area.Methods A total of 286 patients with neonatal hyperbilirubinemia and 250 healthy controls were enrolled.Genotypes of 5 SNPs within BLVRA gene including rs699512,rs1802846,rs7738,rs1637530 and rs2302032 were determined with matrix-assisted laser desorption ionization/time of flight mass spectrometer.The frequencies of genotype,allele,haplotype and their differentiations were analyzed.Results All 5 SNPs had conformed to Hardy-Weinberg equilibrium (all P ＞ 0.05).rs699512 and rs1637530 showed a significant difference between the 2 groups in both allelic and genotypic frequencies (all P ＜ 0.05),but no significant differences were found in the other SNPs(all P ＞ O.05).In recessive model,the frequency of rs699512 GG genotype of patients was significantly lower than that of the healthy control group(OR =0.494,95％ CI:0.276-0.886,P =0.018),while in dominant model,the frequencies of rs699512 GG + AG and rs1637530 TT + CT genotype of patients were significantly lower than that of the healthy control group(OR =0.678,0.627;95％ CI:0.482-0.954,0.444-0.885;P =0.026,0.008).Based on linkage disequilibrium analysis and haplotype construction,rs1637530,rs2302032,rs699512 and rs1802846 locus in the same area.Based on haplotype CGAT,TGGT,CTAT and CGGT had significant differences between the 2 groups (all P ＜ 0.05),and could reduce the risk of high blood bilirubin (OR =0.588,0.687,0.501;95％ CI:0.434-0.797,0.496-0.952,0.250-1.004).Conclusions rs699512 and rs1637530 may be associated with neonatal hyperbilirubinemia,A allele in rs699512 and C allele in rs1637530 may be associated with significantly increased risk of neonatal hyperbilirubinemia.
