Study progress of role of Toll-like receptor 9 in pathogenesis of viral myocarditis

VernacularTitle:Toll样受体9在病毒性心肌炎中作用的研究进展
Author: Shu NIE ¹ ; Hui WANG ; Mingli FANG ; Yanyan HAN
Author Information

1. 吉林大学第一医院小儿心血管科
Keywords: Toll - like receptor 9; Myocarditis; Treatment
From: Chinese Journal of Applied Clinical Pediatrics 2018;33(1):78-80
CountryChina
Language:Chinese
Abstract: Toll - like receptors represents the first line of defense against foreign pathogens and play an essen-tial role in the innate immune response. Toll - like receptor 9(TLR9)is a major receptor mediating CpG DNA signal transduction,which can not only resist inflammation but also induce inflammatory damage. Studies show that the activa-tion of TLR9 which mediated by endogenous nucleic acid released during viral myocarditis (VMC)can cause the heart damage and be involved in the process of VMC. Further study on the role of TLR9 signal in VMC will provide a theoreti-cal foundation for further revealing the pathogenesis of VMC and seeking effective treatment.