The progress of TBX20 gene mutation and all kinds of congenital heart diseases
10.3760/cma.j.issn.2095-428X.2018.01.020
- VernacularTitle:TBX20基因突变与各类先天性心脏病发生的研究进展
- Author:
Zhenzhen QIN
1
;
Caixia LIU
Author Information
1. 山西医科大学儿科医学系
- Keywords:
Congenital Heart disease;
TBX20 gene;
Gene mutation
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(1):75-77
- CountryChina
- Language:Chinese
-
Abstract:
TBX20 gene encodes a T - box transcription factor,which plays an important role in cardiac deve-lopment and in maintaining the maturation of cardiac function. TBX20 mutations are related to a variety of human con-genital heart diseases (CHD)that include atrial septal defect,ventricular septal defect,tetralogy of Fallot,double outlet right ventricle,dilated cardiomyopathy and other valvular diseases. This review focuses on the relationship between TBX20 gene and the development of heart,the TBX20 gene mutations newly found in patients with various CHD in re-cent years and their relationship,which will provide guide for further clinical research and possible intervention.
