Changes in 25 hydroxyvitamin D level in school-aged children with orthostatic hypertension
10.3760/cma.j.issn.2095-428X.2018.01.008
- VernacularTitle:学龄期直立性高血压患儿25-羟维生素D水平变化
- Author:
Xiaohuan SUN
1
;
Runmei ZOU
;
Xuemei LUO
;
Jihong LIU
;
Fang LI
;
Ping LIU
;
Jiemin LI
;
Cheng WANG
Author Information
1. 410011长沙,中南大学湘雅二医院儿童医学中心儿童心血管专科,中南大学儿科学研究所
- Keywords:
25 hydroxyvitamin D;
School - aged children;
Orthostatic hypertension
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change in 25 hydroxyvitamin D[25 -(OH)D]level in school - aged children with orthostatic hypertension (OHT). Methods Nineteen cases of school - aged children with OHT confirmed diagnosis by head - up tilt table test at the Department of Pediatric Cardiovasology,Children′s Medical Center,the Second Xiangya Hospital,Central South University,from October 2014 to February 2017,were selected as OHT group, including 17 males and 2 females,and their ages were from 7 to 14(11. 21 ± 2. 70)years old. Nineteen healthy children including 17 males and 2 females and aged 8 to 14(11. 05 ± 2. 35)years old who had a healthy examination of child care at the hospital in the same period were selected as healthy control group. In two groups of children all possible basic diseases were eliminated,such as severe liver and kidney disease,abnormal thyroid function and metabolic bone disease and/ or the long - term use of 25 -(OH)D metabolism drugs,accepted the serum 25 -(OH)D detection. Results (1)There was no significant difference in age and gender between the OHT group and the healthy control group(t = 0. 559,P > 0. 05;χ2 = 0. 000,P > 0. 05). The 25 -(OH)D levels were significantly lower in the OHT group than those in the healthy control group [(39. 62 ± 10. 65)nmol/ L vs. (64. 83 ± 10. 28)nmol/ L,t = - 7. 422,P <0. 01]. (2)25 -(OH)D levels had no correlation with age,gender,height,body mass,systolic pressure,or diastolic blood pressure (r = 0. 254,0. 047,0. 195,0. 019,- 0. 191,- 0. 184,all P > 0. 05). Taking 25 -(OH)D level as dependent variable,age,gender,height,body mass,systolic pressure,diastolic blood pressure as independent variables, multiple stepwise regression equation to predict 25 -(OH)D level was not fit. Conclusion Lower level of 25 -(OH)D may be one of the mechanisms for the onset of the school - aged children with OHT.
