Immune pathogenesis of Henoch-Sch(o)nlein purpura in children

VernacularTitle:儿童过敏性紫癜免疫机制研究
Author: Wei YIN ¹ ; Jing CHEN
Author Information

1. 华中科技大学同济医学院附属武汉市儿童医院风湿免疫科
Keywords: Henoch-Sch(o)nlein purpura; Immunology; Intestinal mucosal barrier function; Pathogenesis
From: Chinese Journal of Applied Clinical Pediatrics 2017;32(21):1604-1607
CountryChina
Language:Chinese
Abstract: Henoch Schonlein purpura (HSP) is a multiple immune mediated systemic immune vasculitis with an immune complex characterized by deposition of small blood vessels in the affected tissue.HSP complex etiology,infection,food and drugs can cause disease.Its exact pathogenesis is still not clear,may be related to abnormal immune functions,IgA immune complex deposition,T lymphocyte dysfunction,abnormal lymphocyte activation,B interleukin (IL)-17,IL-21,IL-6,visfatin,IL-8 secretion,and intestinal mucosal barrier dysfunction and so on.