Analysis of the Coefficient of Variation for the Internal Quality Control of Hemoglobin A2 and Hemoglobin F from 2014 to 2017
10.3969/j.issn.1671-7414.2018.02.039
- VernacularTitle:2014～2017年我国临床实验室HbA2和HbF检测室内质控变异系数分析
- Author:
Zhi-Xin ZHANG
1
;
Wei WANG
;
Fa-Lin HE
;
Kun ZHONG
;
Shuai YUAN
;
Jia-Li LIU
;
Yu-Xuan DU
;
Zhi-Guo WANG
Author Information
1. 北京医院国家老年医学中心卫生部临床检验中心/北京市临床检验工程技术研究中心
- Keywords:
hemoglobin A2;
hemoglobin F;
internal quality control;
coefficient of variation;
thalassemia
- From:
Journal of Modern Laboratory Medicine
2018;33(2):143-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the internal quality control(IQC) of hemoglobin A2 (HbA2) and hemoglobin F (HbF) from 2014 to 2017 in China.Methods The results of IQC were collected from the laboratories which participated in external quality assessment (EQA) of National Center for Clinical Laboratories (NCCL) from 2014 to 2017,then the coefficient of variation (CV) was compared with 1/3TEa (6.67 ％),1/4TEa (5 ％).The proportion of laboratories meeting criteria were calculated to analyze IQC of HbA2 and HbF in China.The data were grouped based on the instruments used in laboratories,the acceptable rates of CVs of HbA2 and HbF in each group under two criteria in 2017 were calculated,respectively.Results In HbA2,more than 84％ of participant laboratories met 1/3TEa criteria and 70.83％ ～84.47％ of laboratories met 1/ 4TEa criteria.In HbF except for 2015,the more than 80％ laboratories whose month and cumulative CVs met 1/3TEa and 1/4TEa criteria accounted for 68.42 ％ ～ 85.07 ％,respectively.Under 1/3TEa and 1/4TEa criteria,sebia capillarys 2 instru ment and fully automatic hemoglobin analyzer bole Variant Ⅱ instrument group the acceptable rates of CVs above 85％,showed good precision for HbA2 and HbF detection.Conclusion At present,the precision level of HbA2 and HbF need to be further improved in laboratories of China,especially HbF.Laboratory should continue to strengthen the internal quality control,establish strict internal quality system to improve detection capacity.
