Analysis of Changes in Plasma Endothelial Protein C Receptor and Thrombomodulin Level in Patients with Joint Replacement During Perioperative Period
10.3969/j.issn.1671-7414.2018.02.035
- VernacularTitle:关节置换围术期患者血浆内皮细胞蛋白C受体和血栓调节蛋白水平变化分析
- Author:
Hui-Ru ZHAO
1
;
Cong WANG
;
Yu SU
;
Hui-Ying ZHANG
Author Information
1. 北京积水潭医院检验科
- Keywords:
endothelial cell protein C receptor;
thrombomodulin;
joint replacement
- From:
Journal of Modern Laboratory Medicine
2018;33(2):125-126,133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the level of plasma endothelial cell protein C receptor (EPCR) and thrombomodulin (TM)in the perioperative period of artificial joint replacement.Methods 119 patients (male 32,female 87,age distribution 57.75 ±12.04) who underwent total knee replacement and total hip arthroplasty from March to June 2015 in Department of Orthopedics of Beijing Jishuitan Hospital were selected.The levels of plasma endothelial cell EPCR and TM were compared be fore and after operation for 1 and 3 days.Results ①The concentration of plasma EPCR on the first day after surgery was reduced by 40.34％ compared with preoperative,and on the third day after surgery reduced by 49.45％ compared with pre operative,and on the third day after surgery was reduced by 15.26％ compared with the first day after surgery.The differences were all statistically significant (F=5.63,P＜0.05).②The concentration of plasma TM on the first day after surgery was reduced by 12.77％ compared with preoperative,and on the third day after surgery reduced by 40.53％ compared with preoperative,and on the third day after surgery was reduced by 31.83％ compared with the first day after surgery.The differences were all statistically significant (F=7.87,P＜0.05).Conclusion The concentration of EPCR and TM were pro gressively reduced within 3 days after arthroplasty.
