Clinical Value of Serum Ferritin Detection in Patients with Rheumatoid Arthritis Complicated with Anemia
10.3969/j.issn.1671-7414.2018.02.033
- VernacularTitle:类风湿关节炎并发贫血女性患者血清铁蛋白检测的临床价值
- Author:
Wei ZHANG
1
;
Run-Qing ZHANG
;
Lei YU
Author Information
1. 北京市昌平区中西医结合医院
- Keywords:
rheumatoid arthritis;
anemia;
ferritin
- From:
Journal of Modern Laboratory Medicine
2018;33(2):118-120,124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of serum ferritin (sFt) detection in patients with rheumatoid arthritis (RA) complicated with anemia.Methods From January 2014 to December 2016,154 female RA patients hospitalized at Bet jing Changping Hospital of Integrated Chinese and Western Medicine were enrolled and patients without other autoimmune diseases,severe liver and kidney disease,inflammatory infections and malignant tumors were excluded.At the same time,60 age-matched healthy physical examination were selected as a reference.The two groups were generally recorded physical ex amination,laboratory tests and activity index assessment.Comparison of the results of each group for statistical processing.Results The body mass index (BMI) of patients with anemia complicated with anemia (22.69± 3.89 kg/m2 vs 24.51 ± 3.61 kg/m2,t=-3.39,P＜0.001) and serum iron [9.95 (7.75)μmol/L vs 13.30 (7.80)μmol/L,F=-1.98,P＜0.001].However,the RA activity score (DAS28) and various activity indexes were significantly higher than those of non-concurrent anemia (F=1.71～2.14,all P＜0.05).However,there was no significant difference in sFt levels between the two groups (F=0.24,P=0.659).Patients with RA complicated with anemia had significantly higher ESR in patients with high sFt levels [29 (43)mm/h vs 59 (53)mm/h,F=4.35,P＜0.001] and had higher serum lipids,hypertension,diabetes.The incidence of cardiovascular disease,osteoporosis and hyperlipidemia was also higher,but the difference was not statistically significant.Conclusion RA complicated with anemia could aggravate the patient's condition.sFt may be used to assist the diagnosis and treatment of patients with RA complicated with anemia and monitor the occurrence of RA complications.
