Study on the Promoter Region-149C＞T and-579G＞T Polymorphism of DNMT3B with Genetic Susceptibility to Esophageal Cancer of Han Population in Jiangsu Suqian

VernacularTitle:江苏宿迁地区汉族人群DNMT3B基因启动子区-149C＞T和-579G＞T多态性与食管癌易感性的分析
Author: Wei QIU ¹ ; Wei HU ; Jian-Jiang ZHAO ; Su-Mei CHEN ; Dong-Sheng LIU
Author Information

1. 宿迁市人民医院检验科
Keywords: esophageal cancer; DNMT3B; SNP
From: Journal of Modern Laboratory Medicine 2018;33(2):28-30
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of DNA methyltransfcrase 3B (DNMT3B) promoter region single nucleo tide polymorphism (SNP)-149C＞T and-579G＞T with genetic susceptibility of esophageal cancer (EC) of Han population in Jiangsu Suqian.Methods Gcnotypes of the-149C＞T and 579G＞T locus in DNMT3B promoter region were examinedby polymerase chain reaction with restriction fragment length polymorphism (PCR RFLP) in 246 esophageal cancer patients and 240 healthy controls.Results In-149C＞T site,the distributions of genotypes TT compared with CT in the EC group and the controls were no significant difference (x2 =0.089,P＞0.05).In-579G＞T site,the distributions of genotypes TT compared with GT+GG in the EC group and the controls were no significant difference (x2 =0.649,P＞0.05).When strat ified by age and gender,there was no significant difference in the EC group and the controls in both two sites (x2 =0.044～0.876,all P＞0.05).Conclusion The DNMT3B promoter region-149C＞T and-579G＞T were not associated with the genetic susceptibility of esophageal cancer.