Differential Diagnosis Value of Combined Detection NT-ProBNP and cTnⅠ for Different Types of Arrhythmia
10.3969/j.issn.1671-7414.2018.01.025
- VernacularTitle:NT-ProBNP和cTnⅠ联合检测对心律失常不同类型的鉴别诊断价值探讨
- Author:
Wei-Zhen ZHANG
1
;
Li XIANG
;
Shan HUANG
;
Ye TIAN
Author Information
1. 贵州医科大学检验学院
- Keywords:
N-terminal pro-brain natriuretic peptide(NT-proBNP);
cardiac troponinⅠ (cTnⅠ);
arrhythmia;
diagnosis;
differential diagnosis
- From:
Journal of Modern Laboratory Medicine
2018;33(1):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide(NT-proBNP) and cardiac troponinⅠ (cTnⅠ) in cardiac arrhythmia.And the value of differential diagnosis between different types of arrhythmia.Methods The 114 patients with arrhythmia inpatients diagnosed were collected as the disease group and 108 healthy subjects were collected as the control group in Department of Cardiology,Guizhou Province People's Hospital from May 2016 to April 2017.The serum levels of NT-proBNP and cTnⅠ were detected by chemiluminescence method.All the data were tested for normality and homogeneity of variance.T test was used to compare the serum levels of NT-proBNP and cTnⅠ between patients with arrhythmia and control group.The level of serological differences of NT-ProBNP and cTnⅠ in patients with ventricular premature beats,atrial flutter,atrial fibrillation and ventricular tachycardia were compared by One-way ANOVA.Results There was no significant differences in sex and age between the disease group and the control group (t=0.24,1.47,all P＞ 0.05).Compared with the control group,the serum levels of NT-proBNP (855.96 ± 101.46 pg/ml vs 369.77± 194.88 pg/ml) and cTnⅠ ± 0.43 ng/ml vs 0.037 ± 0.015 ng/ml) were increased,and the serum levels of NT-proBNP and cTnⅠ were significantly higher than those in healthy control group(t=2.29,5.68,all P＜0.05).The serum level of NT-pro BNP in atrial flutter patients(1 427.07 pg / ml) and the serum level of cTnⅠ(2.52 ng/ml) in ventricular tachycardia patients were the highest in premature ventricular contractions,atrial flutter,atrial fibrillation,ventricular tachycardia and other types of arrhythmia.There had different distribution (P＜0.05) of NT-pro BNP and cTnⅠ serum levels among the four kinds of diseases.Conclusion The serum levels of NT-pro BNP and cTnⅠ have some reference value in the diagnosis of arrhythmia and in the differential diagnosis of different types of arrhythmia.
