Perioperative Changes of Serum Biochemical Markers in Patients with PCI
10.3969/j.issn.1671-7414.2018.01.009
- VernacularTitle:血清多种生化指标在PCI患者围术期的浓度变化
- Author:
Xu-Zhen QIN
1
;
Dan-Chen WANG
;
Yi-Cong YE
;
Guo-Dong TANG
;
Li-An HOU
;
Li LIU
;
Jun LU
;
Ting-Ting YOU
;
Hong-Lei LI
;
Ling QIU
Author Information
1. 中国医学科学院北京协和医院检验科
- Keywords:
percutaneous coronary intervention;
heart-type fatty acid-binding protein;
ischemia modified albumin;
interleukin;
tumor necrosis factor;
myeloperoxidase
- From:
Journal of Modern Laboratory Medicine
2018;33(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the perioperative changes of h-FABP,IMA,IL-2R,IL-6,IL-8,TNF-α and MPO in patients with PCI.Methods The serial serum samples from 34 patients were collected from November of 2011 to February of 2012 in coronary care unit of Peking Union Hospital on separately 2,4,8 and 24 hours after PCI,then IL2R,IL6,IL8,TNF-α,h-FABP,IMA and MPO were measured.Results MPO,h-FABP and CKMB increased dramatically at 2 hours after PCI(Z value were separately-3.621,-5.123 and-2.789 compared with the level at 2 h and 24 h,all P＜ 0.05),and h-FABP within 24 hours fell into the normal range.MPO dropped quickly after 4 hours of surgery and CKMB peaked at 4 hours,then decreased.The concentration of CK and cTnⅠ rose up at 4h (Z value were separately-2.803 and-2.31 compared with the level at 2h and 24 h,all P＜0.05) and declined with a climax at 8h after PCI.The correlation coefficient of CKMB and CK with cTnⅠ were higher than 0.6.Conclusion This study provided an overview of the change of multi-biomarkers following PCI,which gave a valuable information for clinical treatment.
