Correlative Study between Detection of Human Serum Helicobacter Pylori SodB Antibody and the Occurrence of Gastric Cancer
10.3969/j.issn.1671-7414.2018.01.006
- VernacularTitle:人血清幽门螺杆菌SodB抗体检测与胃癌发生的相关性研究
- Author:
Wen-Jing TIAN
1
;
Dian-Li LIU
;
Hui-Min LIU
;
Qing FAN
;
Wen-Zhen XIE
;
Ying-Zi DONG
Author Information
1. 哈尔滨医科大学公共卫生学院
- Keywords:
gastric cancer;
Helicobacter pylori;
SodB;
serum antibody;
case-control study
- From:
Journal of Modern Laboratory Medicine
2018;33(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the level of serum iron-cofactored superoxide dismutase (SodB) antibody encoded by Helicobacter pylori (H.pylori) genome in infected populations of H.pylori and the occurrence of gastric cancer.Methods Serum samples from 114 cases and 104 control were collected.Indirect ELISA was used to detect serum SodB antibody level in case group and control group.The relationship between serum SodB antibody level and GC risk was analyzed by conditional logistic regression.The value of SodB in serological screening of gastric cancer was analyzed and evaluated by the receiver operating characteristic (ROC) curve.Results The level of serum SodB antibody was correlated with the occurrence of gastric cancer in subjects with OR=2.287 (95％CI:1.191～4.391)(P＜0.05).The optimal cutoff value of SodB for screening gastric cancer was determined by using receiver operating characteristic (ROC) curve,and it was 0.028 0.The area under the ROC curve for subjects was 0.575 (95 ％ CI:0.501 ～ 0.649).Conclusion The level of serum H.pylori SodB antibody was associated with the occurrence of gastric cancer.SodB alone was not effective in screening gastric cancer.It might be used in combination with other biomarkers of gastric cancer to improve further screening of gastric cancer.
