Analysis on Effect and Mechanism of Bu-Yang Huan-Wu Decoction of Alzheimer's Disease Mice
- VernacularTitle:补阳还五汤对阿尔茨海默病小鼠的影响及机制研究
- Author:
Xiufang YU
1
;
Rui DONG
;
Ling CAO
;
Yueying WANG
;
Hainan GAO
;
Fang GENG
;
Guoliang LIU
;
Ning ZHANG
Author Information
- Keywords: Alzheimer's disease; Bu-Yang Huan-Wu decoction; APP/PS1 double transgenic mice; behavior test; inflammatory factor
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(11):1846-1850
- CountryChina
- Language:Chinese
- Abstract: This study was aimed to investigate the effects of Bu-Yang Huan-Wu (BYHW) decoction to the learning and memory ability of APP/PS1 double transgenic mice through two behavior tests,in order to observe the Alzheimer's disease (AD) treatment effect of BYHW decoction.A total of 60 APP/PS1 double transgenic mice were randomly divided into five groups,which were the model group,the hydrochloride group,the high-,middle-,and low-dose BYHW decoction group,with ten rats in each group.The C57BL/6J mice were used as the control group.After 30 days of drug administration,all mice were subjected to behavior tests,including new object recognition experiment and step-through task.Western blot was used to detect changes of inflammatory factors,including IL-6 and TNF-α,in hippocampus of mice.The results showed that compared with the model group,the high-and middle-dose BYHW decoction can significantly decrease inflammatory factors of IL-6 and TNF-α expression in hippocampus of APP/PS1 mice.It can also obviously improve the learning and memory ability of APP/PS1 mice.It was concluded that BYHW decoction can significantly decrease the inflammatory factor expression in APP/PS 1 double transgenic AD model mice.It can obviously improve its learning and memory ability,which can be used in the treatment of AD.
