Study on Mechanism of Huang-Lian Jie-Du Decoction on Atherosclerosis Rats Based on Anti-inflammatory And Antioxidant
- VernacularTitle:基于抗炎和氧化应激角度研究黄连解毒汤对动脉粥样硬化大鼠作用机制
- Author:
Lanbin YU
1
;
Yu CHEN
;
Guoliang XU
;
Le YANG
;
Jiali HU
;
Jiangnan DUAN
;
Li JIANG
Author Information
- Keywords: Huang-Lian Jie-Du decoction; anti-inflammatory; oxidative stress; atherosclerosis; rat
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(11):1841-1845
- CountryChina
- Language:Chinese
- Abstract: This paper was aimed to study the effects of Huang-Lian Jie-Du decoction (HJD) on contents of oxidized low density lipoprotein (Ox-LDL),monocyte chemoattractant protein (MCP-1),vascular cell adhesion molecule (VCAM-1),malondialdehyde (MDA),and superoxide dismutase (SOD) of atherosclerosis (AS) rats' liver homogenate.Male SD rats were randomly divided into six groups,which were the normal control group,model group,positive control group (lovastatin),and the low-,middle-,high-dose HJD groups,with ten rats in each group.Except for the normal control group fed with normal diet,others were fed with high-fat diet,and regularly injected the vitamin D3.All groups were gavaged once daily from the 3rd week for 8 weeks until they were sacrificed.The results showed that compared with the normal control group,contents of MCP-1,VCAM-1 and Ox-LDL in the liver homogenate of the model group had significantly increased (p ＜ 0.05),after drug administration,all indexes mentioned above in the positive control group,the low-and middle-dose HJD group were decreased significantly (p ＜ 0.05);contents of MCP-1 and VCAM-1 of the high-dose HJD group decreased obviously (p ＜ 0.01);MDA content of liver homogenate increased significantly,after drug administration,contents of the positive control group and the low-dose HJD group decreased significantly (p ＜ 0.05);SOD content decreased significantly,after drug administration,contents of both the positive control group and the high-dose group increased significantly (p ＜ 0.05).It was concluded that HJD may play a role in AS intervention.Its mechanism may be related to its anti-inflammatory and antioxidant reaction.
