Drug Discovery Investigation of Nourishing Kidney-yin And Warming Kidney-yang Granules in Prevention And Treatment of Primary Osteoporosis Based on Theory of "Treating Both Disease And Traditional Chinese Medicine Syndrome"
- VernacularTitle:滋肾阴、温肾阳颗粒及关键药对防治原发性骨质疏松症“病证结合”新药创制研究
- Author:
Dongfeng ZHAO
1
,
2
,
3
;
Bing SHU
;
Dezhi TANG
;
Yan ZHANG
;
Yongjian ZHAO
;
Chenguang LI
;
Qiang WANG
;
Qianqian LIANG
;
Xuejun CUI
;
Yanping YANG
;
Hao XU
;
Qi SHI
;
Yongjun WANG
Author Information
- Keywords: Primary osteoporosis; nourishing kidney-yin granules; warming kidney-yang granules; treatment based on both the disease and traditional Chinese medicine syndrome; systematic regulatory effect
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(11):1768-1772
- CountryChina
- Language:Chinese
- Abstract: Nourishing kidney-yin (NKY) granules and warming kidney-yang (WKY) granules represent one of the prescriptions that prescribed in treating primary osteoporosis (POP) in light of tonifying kidney and nourishing essence principle as well as the theory of "treating both the disease and traditional Chinese medicine (TCM) syndrome".Both granules were created through the systematic analysis of clinic prescriptions by Professor Shi Qi.Consequently clinical investigations have well established that NKY granules significant improved bone mineral density (BMD) as well as relieved the kidney-yin deficiency syndromes in POP patients.Meanwhile,WKY granules relieve kidney-yang deficiency syndrome and the quality of life (QOL).What is more,pharmacological study established the application of common cnidium fruit,and fructus ligustri lucidi alleviated bone loss in OVX-induced mice.In addition,investigation with effective components identified that both NKY and WKY granules play systematic pharmacological effects on bone remodeling by regulating the expression of BMP/Smad,Wnt/β-catenin,RANKL/RANK/OPG axis,and Notch.The drug discovery was performed by the lead of traditional Chinese medicine (TCM) theory.It is one successful transformation investigation based on pharmacological effects,clinical intervention,animal model,cell culture and molecular investigation.
