Research on Acupoint-molecular Biology Effect Network Based on Complex Network
- VernacularTitle:基于复杂网络的穴位-分子生物学效应研究
- Author:
Manting HUANG
1
;
Lei LEI
;
Haiyan LI
;
Ce YANG
;
Ying NIE
;
Li KANG
Author Information
- Keywords: Literature study; acupuncture; acupoint; gene; complex network
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(10):1654-1660
- CountryChina
- Language:Chinese
- Abstract: This paper was aimed to study the molecular mechanism of acupoint biology effect on acupuncture experiment articles.The acupuncture experiment articles in CNKI,Wanfang Data Resource Library and the China Biomedical Literature Database (CBM) were searched.The literature on acupoint and related genes were selected according to the literature inclusion criteria and exclusion criteria.The acupoint and corresponding genes in the literature were collected and analyzed by software written in Python,Cytoscape 3.3.0 and MECODE algorithm.The results showed that 2136 articles were collected,with 233 acupoints and 793 genes.Acupoints in the top 10 frequency were ST36 (Zusanli),GV20 (Baihui),PC6 (Neiguan),GV26 (Shuigou),GV14 (Dazhui),SP6 (Sanyinjiao),BL23 (Shenshu),LI11 (Quchi),GV16 (Fengfu) and GB34 (Yanglingquan).Genes in the top 10 frequency were BCL2,FOS,BDNF,Bax,CASP3,TNFA,GFAP,NGF,HSP70 and IL1B.Acupoint-groups in the top 5 frequency were GV14 (Dazhui)-GV20 (Baihui),GV26 (Shuigou)-GV20 (Baihui),GV20 (Baihui)-ST36 (Zusanli),SP6 (Sanyinjiao)-ST36 (Zusandi),PC6 (Neiguan)-GV26 (Shuigou).ST36 (Zusanli) was in the center of the acupoint-gene network.Through module analyzing,there were some genes belong to different pathways and some acupoints in one network module.It was concluded that ST36 (Zusanli) was the core acupoint in the acupoint experiment study,the stomach meridian of foot Yangming may be closely related with the metabolic pathway.This finding may provide new research ideas for clinical and experimental research.
