MR Imaging of Fracture: MR Pathologic Correlation of Experimentally Produced Fractures on Rabbit Tibias.
10.3348/jkrs.1996.35.3.409
- Author:
Heung Sik KANG
1
;
Jin Mo KOO
;
Woo Ho KIM
Author Information
1. Department of Radiology, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Fractures, MR;
Extremities, fractures
- MeSH:
Bony Callus;
Fracture Healing;
Freezing;
Gadolinium DTPA;
Hematoma;
Magnetic Resonance Imaging*;
Rabbits;
Tibia*
- From:Journal of the Korean Radiological Society
1996;35(3):409-416
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate MR imaging characteristics of the fracture healing process. MATERIALS AND METHODS: We performed MR-pathologic correlation of fractures experimentally produced by the three-point beding system inthe proximal tibias of 24 New Zealand white rabbits. Axial spin echo T1-weighted image(T1WI), T2-weighted image(T2WI) and T1WI after gadopentetate dimeglumine injection were obtained 1-28 days after fracture MR imaging was followed by freezing, sectioning along the MR imaging planes and histopathologic examinations. Changes in MR signal around the fractures were correlated with histopathologic findings. RESULTS: Hematomas and inflammatory tissue around the fractures, noted one day after fracture, showed slightly increased homogeneous signal intensityon T1WI, heterogeneous hyperintensity on T2WI and heterogeneous contrast enhancement. Granulation tissue,cartilage, and immature osteoid, noted 1-4 weeks after fracture, showed iso- or slight hyperintensity on T1WI, hyperintensity on T2WI and contrast enhancement. Hard callus containing ossified osteoid showed hypointensity onboth T1WI and T2WI without contrast enhancement. CONCLUSION: The characteristics of MR signal intensity and contrast enhancing pattern can explain the histopathology of the fracture healing process.
