The Mechanism Study of Micro-substance of Chinese Medicine——The Discovery and Elucidation of Effective Substance and Mechanism of Chinese Medicine via the Theory of Synthetic Lethality
- VernacularTitle:微量中药成分的起效机制研究不容忽视——“遗传协同致死”模式有助于发现并阐释中药显效物质基础及起效机制
- Author:
Zhonghong WEI
1
,
2
;
Suyun YU
;
Wenxing CHEN
;
Aiyun WANG
;
Yin LU
Author Information
- Keywords: micro-substance of Chinese medicine; synthetic lethality; environment stresses; reverse pharmacology; effective substance
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(9):1424-1429
- CountryChina
- Language:Chinese
- Abstract: The elaboration of the mechanism and pharmacodynamic substance are the main obstacles to the modernization of Chinese medicine.The rich ingredient of Chinese medicine is almost attention,with a research strategy of forward pharmacology.This strategy often neglects the study of trace components of Chinese medicine.Synthetic lethality,a extremely complex gene interactions,is to magnify the effects of the co-regulation of biological effects (＞ 1 000 times).The theory of synthetic lethality has achieved good results in the development of anti-tumor drugs,including the discovery of PARP inhibitors,the clinical use of chemotherapy drug addition and attenuation combination.In view of this,this research model may be used to elucidate trace effective substance.Based on the reverse thinking of "targetcomponent-effect"and clear synergistic targets,the mechanism of traces and weak-potency substance of traditional Chinese medicine was studied,and the synergistic combination of potential was found.
