Research on Stability of Tannin Part in Phyllanthus Emblica L.in Artificial Gastric And Intestinal Juice
10.11842/wst.2017.08.023
- VernacularTitle:藏药余甘子鞣质部位主要药效成分在人工胃肠液中的稳定性研究
- Author:
Lingfang WU
1
;
Ting YE
;
Linjin LIANG
;
Wenyi LIANG
;
Wenjing CHEN
;
Shi LI
;
Yaping CUI
;
Qi QI
;
Lanzhen ZHANG
Author Information
1. 北京中医药大学中药学院 北京100102
- Keywords:
Phyllanthus emblica L.;
tannin part;
artificial gastric and intestinal juice;
stability
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(8):1386-1390
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the stability of tannin parts in Phyllanthus emblica L.in artificial gastric and intestinal juice,in order to provide a foundation for in vivo studies of Phyllanthus emblica L.HPLC-UV was used to determine the contents of main ingredients.The results showed that stability of main ingredients of tannin parts in Phyllanthus emblica L.,including gallic acid (GA),corilagin and ellagic acid (EA),in the artificial gastric juice.The content change was not obvious.The residual content was within 100％.The half-life was above 90 h.They were unstable in the artificial intestinal juice.The content was first increased and then decreased.The residual content was 100-300％.The half-life was above 10 h.It was concluded that the tannin parts in Phyllanthus emblica L.was stable in artificial gastric juice.And content changes of main components were not obvious.The tannin parts in Phyllanthus emblica L.were unstable in artificial intestinal juice.The main ingredients were first increased and then decreased.It was speculated that macromolecule can hydrolyze tannin part into small molecules.Hnwever,as time increases,all components may be decomposed.
