Effect of Kai-Xin Jie-Yu Decoction on Regulation of Neurovascular Unit of Depression
10.11842/wst.2017.08.017
- VernacularTitle:基于神经血管单元稳态探索开心解郁方抗抑郁作用机制
- Author:
Ying ZHANG
1
;
Liansheng WANG
;
Yuxia CHENG
;
Shijing HANG
Author Information
1. 中国中医科学院广安门医院 北京100053
- Keywords:
Depression;
neurovascular unit;
Kai-Xin Jie-Yu decoction;
action mechanism
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2017;19(8):1355-1359
- CountryChina
- Language:Chinese
-
Abstract:
The neurovascular unit (NVU) is a dynamic functional module composed of neurons,microglia,blood-brain barrier (BBB) and the extracellular matrix that maintains the integrity of brain tissues.The chief members of NVU are one of the structural bases of the development of nervous system diseases.And they are involved in the pathological process of depression.The NVU instability of depression is characterized by the uncoupling of nerve and blood vessels,the increase of BBB permeability and the inflammatory response.Traditional Chinese medicine (TCM) has many advantages in the treatment of depression,and the effect of Kai-Xin Jie-Yu (KXJY) decoction in treating depression is remarkable.The purpose of this study was to explain the effect of KXJY decoction on NVU in terms of the functional connectivity of brain white matter,the protection of neurons and glial cells,the protection of vascular endothelial cells,the repair of BBB and the reduction of inflammation.It provided a new theoretical basis and method for the treatment of depression in TCM.
