Mechanism of Neuropsychiatric Comorbidity Based on the Theory of "Same Treatment for Different Diseases" in Traditional Chinese Medicine
- VernacularTitle:基于中医学“异病同治”理念探究神经精神疾患共病机制
- Author:
Yang SUN
1
,
2
;
Huili JIANG
;
Jun LU
;
Yutong FEI
;
Xinjing YANG
;
Bingcong ZHAO
;
Ya TU
Author Information
- Keywords: Stress; inflammatory response; neuropsychiatric disorders; comorbidity
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(8):1294-1299
- CountryChina
- Language:Chinese
- Abstract: This study was aimed to investigate the mechanism underlying the neuropsychiatric comorbidity in the process of "stress"-"inflammation"-"comorbidity",from the perspective of traditional Chinese medicine (TCM) basic theory in combination with our previous 20-year findings.Notably,the neural-psychiatric comorbidity between psychiatric disorders,including depression,schizophrenia and anxiety,and systemic diseases,such as ischemic stroke,Alzheimer's disease (AD) and asthma,have something in common in the pathophysiological mechanism.The stress-induced structural and functional changes in the brain,the stress-initiated diversely structural and neurobiological changes in neurocircuitry,and the stress-mediated neurochemical alterations in neurotransmitter are considered to be involved in the common pathophysiological mechanisms in the neural-psychiatric comorbidity,which initiates a cascade of physiological and psychological processes that contributes to the development of various types of neuropsychiatric disorders.Accordingly,it will be of great significance to investigate mechanisms underlying the neuropsychiatric comorbidity in the process of "stress"-"inflammation"-"comorbidity" under the guidance of the basic theory of "treating disease from the root" and "same treatment for different diseases" in TCM.
