Research Progress on Rapid Antidepressant of Traditional Chinese Medicine
- VernacularTitle:中医药快速抗抑郁研究进展
- Author:
Xin ZHOU
1
;
Wenda XUE
;
Juanjuan TANG
;
Weiwei TAO
;
Haoxin WU
;
Gang CHEN
Author Information
- Keywords: Yue-Ju pill; Gardenia jasminoides; rapid antidepressant; animal model; neural and individualized drug response mechanism
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(8):1283-1288
- CountryChina
- Language:Chinese
- Abstract: Major depression is a public health problem that seriously harms individuals and the society.But one of the major shortcomings of mainstream antidepressant is the delayed onset.Recent series of studies demonstrated that,from a variety of animal models and clinical studies,classic stagnation-removing formula Yue-Ju (Y J) pill has the advantage in rapid antidepressant efficacy,which is similar to the prototype drug ketamine.It has the mechanism of rapid and sustained enhancement of neural plasticity and individual difference in response to YJ pill.The evidence of Gardenia jasminoides (Zhi-Zi) as the monarch component of YJ pill's rapid antidepressant action has also been revealed.The further in-depth research on rapid antidepressant traditional Chinese medicine (TCM) is important for providing the scientific and reliable TCM strategies to treat depression.
