Study on Extraction Process Trajectory for In-line Monitoring of Extraction Process of Lonicera Japonica of Re-Du-Ning Injection
- VernacularTitle:热毒宁注射液金银花提取过程轨迹研究
- Author:
Lei WANG
1
;
Yue YANG
;
Hongye PAN
;
Yongjie CHEN
;
Yong CHEN
Author Information
- Keywords: Re-Du-Ning injection; Lonicera japonica extraction; near-infrared spectrum; multivariate statistical process control; process monitor
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(8):1277-1282
- CountryChina
- Language:Chinese
- Abstract: This study was aimed to develop in-line monitoring of extraction process of Lonicerajaponica in the extraction process trajectory of Re-Du-Ning (RDN) injection.Several batches of near-infrared (NIR) spectrum dates were collected and multivariate statistical process control (MSPC) method was in conjunction with.The results showed that using score,Hotelling T2 and DModX control chart,various normal and abnormal behaviors of the test batches were detected in time by comparison with the extraction process trajectory.It was concluded that the process trajectory for in-line quality control based on NIR spectrum dates and MSPC could indicate the changes of process.It was a feasible technology tool of the total process quality control during traditional Chinese medicine (TCM) manufacturing process.
