Study on Prescription Regularity of Traditional Chinese Medicine in Treating Cirrhosis Based on Machine Learning
- VernacularTitle:基于机器学习的中医治疗肝硬化组方规律研究
- Author:
Wei PEI
1
;
Huikun WU
;
Xiaodong LI
;
Dan XIE
Author Information
- Keywords: Machine learning; cirrhosis; traditional Chinese medicine prescription; prescription regularity
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(6):950-956
- CountryChina
- Language:Chinese
- Abstract: This study was aimed to use machine learning techniques for the prescription regularity of traditional Chinese medicine (TCM) in the treatment of liver diseases in order to provide a reference basis for clinical treatment as well as research and development of new drugs.According to the prescription data of liver disease treatment of the last two years in the hepatology department of a triple-A TCM hospital,the related structure between drugs was firstly found by the complex structure of drugs.And then,association rule,cluster analysis and other unsupervised machine learning methods were used.The prescription regularity of TCM in the treatment of cirrhosis was received through the comparison and analysis.The results showed that there were 589 prescriptions with 257 types of Chinese medicine herbs.The high frequency drug combination included 2 items of 12,3 items of 15,4 items of 14;support ＞ 10％,confidence ＞ 90％ of the association rule include "dried tangerine peel,medicated leaven → largehead atractylodes rhizome," "polyporus umbellatus,dried tangerine peel → largehead atractylodes rhizome" and other 34;through cluster analysis,it showed that Chinese medicine was mainly classified by 5 characteristics.The machine learning result was the same as the constructed complex network.It was concluded that the combination of complex network and machine learning methods in the exploration of prescription regularity of TCM in the treatment of cirrhosis were feasible.It provided clinical treatment of cirrhosis and clues for finding new prescription in the treatment of cirrhosis.
