Risk factors of underestimating diagnosis with ductal carcinoma in situ following core needle biopsy
10.3969/j.issn.1672-8467.2018.03.017
- VernacularTitle:空芯针穿刺活检诊断为乳腺导管原位癌病理低估的影响因素
- Author:
Fu-Wen WANG
1
;
Yu-Chun JIN
;
Shao-Mei FU
Author Information
1. 复旦大学附属妇产科医院乳腺外科 上海 200011
- Keywords:
core needle biopsy;
ductal carcinoma in situ;
underestimation
- From:
Fudan University Journal of Medical Sciences
2018;45(3):397-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors of underestimation from core needle biopsy (CNB) diagnosed ductal carcinoma in situ (DCIS) to invasive cancer after surgical excision.Methods One hundred and fifteen cases of CNB diagnosed DCIS treated in Obstetrics and Gynecology Hospital,Fudan University from Jan.,2010 to Dec.,2016 were analyzed retrospectively.According to postoperative pathological conditions,the cases were divided into underestimation group and non underestimation group.The clinicopathological characteristics of two groups were compared,including age,palpability,tumor diameter,microcalcification,BI-RADS classification and CNB method.Results The overall underestimating rate was 27.0％ (31/115).Univariate analysis found correlation between a palpable lesion,diameter of tumor ＞20 mm,microcalcification,a high BI-RADS classification,use of the 14/16-gauge needle method and underestimation from CNB diagnosed DCIS.Multivariate analysis by Logistic regression showed that diameter of tumor ＞20 mm (OR =0.186,95％CI:0.043-0.810,P =0.025),microcalcification (OR=0.229,95％CI:0.070-0.749,P =0.015),use of the 14/16 gauge needle method (OR =0.171,95 ％ CI:0.043-0.679,P =0.012) were independent risk factors of underestimation from CNB diagnosed DCIS.Conclusions Size of lesion ＞20 mm,microcalcification,use of the 14/16-gauge needle method were independent risk factors of underestimation from CNB diagnosed DCIS.
