Immunosuppressant treatment for delayed graft function in renal transplantion of donation after cardiac death
10.3969/j.issn.1672-8467.2018.02.015
- VernacularTitle:心脏死亡器官捐献肾移植术后肾功能延迟恢复的免疫抑制剂选择
- Author:
Yi-Qun ZHOU
1
Author Information
1. 上海罗氏制药有限公司 上海 201102
- Keywords:
donation after cardiac death;
renal transplantation;
delayed graft function;
immunosuppressant
- From:
Fudan University Journal of Medical Sciences
2018;45(2):240-244
- CountryChina
- Language:Chinese
-
Abstract:
Donation after cardiac death (DCD) is becoming the main source of organ transplantation in China.DCD has increased the incidence of delayed graft function (DGF) when compared with donation after brain death (DBD) in renal transplantation,though previous studies revealed they both have identical long term outcome of grafts.Currently,induction therapy is widely used for preventing DGF.In order to prevent grafts' function,the subsequent maintenance regimens usually include delayed and reduced calcineurin inhibitor (CNI) with strengthened other immunosuppressant,such as mycophenolic acid (MPA).And it should be noticed that,the area under concenration-time curve (AUC) of MPAs is lower when DGF developed.Therefore,the dosage of MPAs in DCD recipients with DGF is more difficult to grasp and therapeutic drug monitoring of MPAs is nessesary in those patients.
