Research progress of autophagy in non-alcoholic fatty liver disease
10.3969/j.issn.1674-8115.2018.06.019?
- VernacularTitle:自噬与非酒精性脂肪性肝病的研究进展
- Author:
Chao-Hui JIAN
1
;
Yu-Qian BAO
Author Information
1. 上海交通大学附属第六人民医院内分泌代谢科
- Keywords:
autophagy;
non-alcoholic fatty liver disease;
lipid deposition;
insulin resistance;
endoplasmic reticulum stress;
mitochondrial dysregulation;
inflammation
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2018;38(6):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease is a type of metabolic liver injury which is closely related to insulin resistance. Now it has become the leading cause of chronic liver diseases worldwide, which is closely related to the high incidence of type 2 diabetes and arteriosclerotic cardiovascular disease. It can progress into cirrhosis and hepatocellular carcinoma. The pathogenesis of non-alcoholic fatty liver disease is complicated and not yet fully elucidated. In recent years, studies have found that autophagy plays an important role in the development of non-alcoholic fatty liver disease, mainly through regulation of insulin resistance, endoplasmic reticulum stress, mitochondrial dysregulation, lipid-toxicity caused by lipid deposition and inflammation.
