Immunohistochemical Study with Carcinoembryonic Antigen in Experimental Bladder Tumor Induced by Administration of N-butyl-N-(4-hydroxybutyl)-nitrosamine.
- Author:
Sun Jin KIM
1
;
Young Kyoon KIM
Author Information
1. Department of Urology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
BBN;
Bladder cancer;
Carcinoembryonic antigen;
Immunohistochemical study;
Cross reactivity of CEA
- MeSH:
Animals;
Carcinoembryonic Antigen*;
False Positive Reactions;
Humans;
Rats;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1990;31(2):159-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Immunohistochemical study with carcinoembryonic antigen (CEA) by peroxidase-antiperoxidase (PAP) method in rat bladder tumor induced by administration of N-butyl-N-( 4-hydroxybutyl)- nitrosamine was performed to know the immunological cross reactivity between human bladder tumor and experimentally induced rat bladder tumor and to evaluate, if all, its role as an indicator of malignant potential in rat bladder tumor. The results revealed 6 false positive reactions regardless of their histologic types and gave us no meaningful informations about ongoing disease process.
