The effects of serum potassium on insulin secretion ability in patients with impaired glucose regulation
10.3760/cma.j.issn.1674-6090.2018.04.016
- VernacularTitle:糖调节异常者血钾水平与胰岛β细胞功能的关系
- Author:
Huihui FAN
1
;
Jian MA
Author Information
1. 浙江省宁波市奉化区人民医院内分泌科
- Keywords:
Serum potassium;
Insulin secretion ability;
Impaired glucose regulation;
Type 2 diabetes mellitus
- From:
Chinese Journal of Endocrine Surgery
2018;12(4):330-334
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether serum potassium can influence insulin secretion ability in pa tients with impaired glucose regulation (IGR).Methods 320 subjects with IGR were enrolled in our study.All subjects underwent a standard OGTT.Their clinical and biochemical parameters were measured.Insulin secretion indices were measured by DI0,DI30,and DI120.Results In IGR,DI0 was negatively correlated with BMI (r=-0.122,P=0.015),total cholesterol (TC) (r=-0.182,P=0.032),low density lipoprotein-cholesterol (LDL-C) (r=-0.1 78,P=0.026) and triglyceride (TG) (r=-0.179,P=0.01 1).DI30 was negatively correlated with TC (r=-0.146,P=0.001),TG(r=-0.192,P=0.027)and LDL-C(r=-0.134,P=0.014).DI120 was negatively correlated with TC(r=-0.222,P＜ 0.001),TG(r=-0.209,P＜0.001)and LDL-C (r=-0.183,P＜0.001) while postively correlated with serum potassium (r=0.208,P＜0.001).The multiple regression model analysis showed that serum potassium (β=0.380,P＜0.001) was independently correlated to DI120.Conclusion In patients with IGR,serum potassium is associated with insulin secretion ability,which may provide a new treatment strategy for preventing IGR into T2DM.
