The relationship between preoperative neutrophils and lymphocyte ratio and prognosis in invasive breast carcinomas of no special type
10.3760/cma.j.issn.1674-6090.2018.03.015
- VernacularTitle:术前中性粒细胞淋巴细胞比值与浸润性非特殊类型乳腺癌预后的关系
- Author:
Ming SHAN
1
;
Ruijie NIU
;
Yongwei LU
;
Yanmin YU
;
Cheng WANG
Author Information
1. 200001,上海市黄浦区中心医院乳腺外科
- Keywords:
Breast cancer;
Neutrophil-to-lymphocyte ratio;
Prognosis
- From:
Chinese Journal of Endocrine Surgery
2018;12(3):238-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic value of preoperative neutrophil-to lymphocyte ratio (NLR) in invasive breast carcinomas of no special type.Methods we retrospectively analyzed the clinical and pathological data of all breast cancer patients at Shanghai Huangpu District Cental Hospital from Jan.2012 to Dec.2012.The optimal cutoff value was obtained by ROC.The difference among variables was calculated by chi-square test.DFS and OS were estimated using Kaplan-Meier method.Cox analysis was performed to analyze clinical parameters for their prognostic relevance.Results A total of 493 were eligible.The optimal cutoff value of NLR was 2.057.The sensitivity was 0.767 and specifity was 0.327 at the optimal cutoff point.Univariate analysis showed that patients with NLR higher than 2.057 had significantly lower DFS (P=-0.001) than patients with NLR equal or lower than 2.057,while the overall survival rate was not statistically different (P=0.131).The Cox proportional multivariate hazard model revealed that higher NLR was independently related with poor DFS with hazard ratio 5.649(95％ confidence interval 3.128-10.201,P=0.002).Conclusions Preoperative NLR is an independent predictor of DFS in breast cancer patients.Further validation and a feasibility study are required before it can be considered for clinical use.
