Expression and correlation of Fascin-1 and EGFR in triple-negative breast cancer and non-triple-negative breast cancer
10.3760/cma.j.issn.1674-6090.2018.02.007
- VernacularTitle:三阴性和非三阴性乳腺癌中Fascin-1和EGFR表达的相关性研究
- Author:
Chaoqun WANG
1
;
Yan WANG
;
Bifei HUANG
;
Zhenming SU
;
Yongming ZHAO
;
Qian WANG
;
Guinv HU
;
Huajun LU
Author Information
1. 浙江省东阳市人民医院/温州医科大学附属东阳医院病理科
- Keywords:
EGFR;
Fascin-1;
Triple-negative breast cancer;
Immunohistochemistry
- From:
Chinese Journal of Endocrine Surgery
2018;12(2):115-117,145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Fascin-1 and EGFR in triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC) and its correlation.Methods According to ER,PR,and HER2 status,breast cancer were categorized into 2 subtypes:70 cases of TNBC and 370 cases of non-TNBC.The immunohistochemical technique,EnVision method,was used to evaluate the expression of Fascin-1 and EGFR in breast cancer.Results Expression rate of Fascin-1 and EGFR protein in TNBC was 88.6％(62/70)and 78.6％(55/70),while it was 19.2％(71/370)and 44.3％(164/370)in non-TNBC,respectively.Fascin-1 expression rate was significantly higher in EGFR positive non-TNBC cases (34.8％,57/164) than in EGFR negative cases (6.8％,14/206)(x2=46.032,P=0.000).The positive rate of Fascin-1 protein in EGFR-positive TNBC cases (92.7％,51/55) was higher than that in EGFR negative cases (73.3％,11/15),and the difference had no statistically significance (x2=2.673,P=0.102).Conclusions EGFR signal pathway may positively regulate Fascin-1 expression in non-TNBC.The relationship between EGFR and Fascin-1 in TNBC is needed for further study.
