Effect of zoledronic acid combined with Jintiange capsule on treatment of postmenopausal osteoporosis
10.3760/cma.j.issn.1674-6090.2017.05.014
- VernacularTitle:金天格胶囊治疗绝经后骨质疏松的临床效果及作用机制
- Author:
Yingjie QI
1
;
Jun CAI
;
Lei GUANG
;
Xiaoqiang SHEN
;
Xiaomin GU
Author Information
1. 浙江省杭州师范大学附属医院骨科
- Keywords:
Jintiange capsule;
Osteoporosis;
Bone mineral density;
Bone metabolism
- From:
Chinese Journal of Endocrine Surgery
2017;11(5):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Jintiange capsule on treatment of postmenopausal osteoporosis (PMOP) and its mechanism.Method 133 patients diagnosed as PMOP and meeting the standard were collected from Oct.2011 to Aug.2015 in our hospital.They were randomly divided into two groups:treatment group and the control group.The control group received calcium and alendronate,while the treatment group received 3 Jintiange capsules 3 times daily on the basis of the control group.The lumbar bone densit (BMD),greater trochanter BMD,femoral neck BMD,Ward triangle BMD,visual analogue score (VAS) of knee and back,the serum levels of bone glaprotein (BGP),alkaline phosphatase (ALP),β-C-terminal telopeptide of type Ⅰ collagen (β-CTX),N-terminal propeptide of type Ⅰ procollagen (PINP) and adverse reactions were recorded before and after treatment.Results The lumbar BMD,greater trochanter BMD,femoral neck BMD,ward triangle BMD of treatment group after treatment were higher than those before treatment and those of the control group (P＜0.05).VAS score of knee and back of treatment group were lower than those of the control group (P＜0.05).The serum levels of BGP,ALP,β-CTX,PINP of treatment group were lower than those of the control group (P＜0.05).The adverse reactions rate of two groups had no significant difference (P＞0.05).Conclusion Jintiange capsule can significantly reduce bone metabolism level,increasing BMD,reducing bone loss,relieving knee and back pain of PMOP,without increasing complication rates,which is worthy to be promoted due to high safety and efficacy.
