The effect of percutaneous kyphoplasty combined with Xianling Gubao capsule in treatment of osteoporotic vertebral compression fractures
10.3760/cma.j.issn.1674-6090.2017.05.013
- VernacularTitle:经皮椎体后凸成形术联合仙灵骨葆胶囊治疗绝经后骨质疏松性椎体骨折的疗效分析
- Author:
Pan CAI
1
;
Xiaoxiao ZHOU
;
Jiajun WU
;
Beigang FU
;
Minghui WANG
;
Xiuhui WANG
;
Yan LU
Author Information
1. 201318,上海市浦东新区周浦医院骨科
- Keywords:
Xianling Gubao capsule;
Osteoporosis;
Percutaneous kyphoplasty;
Bone metabolism
- From:
Chinese Journal of Endocrine Surgery
2017;11(5):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of percutaneous kyphoplasty (PKP) combined with Xianling Gubao capsule on treatment of osteoporotic vertebral compression fractures(OVCF).Methods 118 postmenopausal women diagnosed as OVCF and meeting the standard were collected from Mar.2012 to Jul.2016 in our hospital.They were randomly divided into two groups:observation group and the control group.General information of the two groups were comparable.The patients of the control group received PKP combined with traditional anti-osteoporosis therapy.The patients of observation group received Xianling Gubao capsule on the basis of the control group.The lumbar bone density (BMD,greater trochanter BMD,femoral neck BMD,Ward triangle BMD,the Japanese orthopaedic association(JOA)score,the visual analogue score (VAS) score,the serum levels of osteoprotegerin (OPG),receptor activator of nuclear factor-κB ligand (RANKL)and adverse reactions were recorded during the treatment.Results The lumbar BMD,greater trochanter BMD,femoral neck BMD,Ward triangle BMD of observation group at 6-month after operation were higher than those before operation and those of control group (P＜0.05).The VAS score and JOA score of the observation group were superior to those of the control group at 6-month after operation (P＜0.05).The serum levels of OPG of observation group were higher than those of control group,while the serum levels of RANKL of observation group were lower than those of control group at 6-month after operation (P＜0.05).No severe adverse reactions occurred in the two groups during the treatment.Conclusion Xianling Gubao capsule can significantly improve bone metabolism of postmenopausal women with osteoporotic vertebral compression fractures after percutaneous kyphoplasty,increasing BMD,improving lumbar function,relieving pain,without increasing complication rates.
