Preoperative serum thyroglobulin in prediction of follicular thyroid tumors
10.3760/cma.j.issn.1674-6090.2017.05.011
- VernacularTitle:术前甲状腺球蛋白在甲状腺滤泡性肿瘤的恶性预测分析中的作用
- Author:
Zongping WANG
1
;
Jie KANG
;
Bomin GUO
;
Xianzhao DENG
;
Bo WU
;
Youben FAN
Author Information
1. 山东省立医院西院甲状腺疾病科
- Keywords:
Thyroglobulin;
Thyroid carcinoma;
Thyroid follicular carcinoma;
Logistic regression;
ROC curve
- From:
Chinese Journal of Endocrine Surgery
2017;11(5):391-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze whether preoperative serum thyroglobulin (Tg) can be the indicator for predicting malignancy in follicular thyroid tumors (FTC).Methods A retrospective analysis was done for 125 patients with FTC who had been diagnosed by pathology in our hospital.The patients were grouped into benign group and malignant group.Sex,age,tumor size and preoperative serum Tg concentration were analyzed.Results There were 62 patients in benign group (23 male and 39 female).The mean age was 49 years old,ranging from 19 to 78 years,and the mean diameter of tumors was (3.4±1.374) cm,ranging from 0.1 to 5.5 cm.There were 63 patients in malignant group (13 male and 50 female).The mean age was 46 years old,ranging from 15 to 79 years,and the mean diameter of tumors was (3.14±1.143) cm,ranging from 0.3 to 7 cm.The mean preoperative serum Tg concentration was (299.73± 495.02) ng/ml in malignant group and(48.20 ±43.68)ng/ml in the benign group.Through comparing the two groups,we found age and tumors diameter had no statistical difference between the two groups (P＞0.05),while sex and Tg had statistical difference (P＜0.05).When the cutoff of Tg was 100 ng/ml,the sensitivity and specificity for the diagnosis of malignancy was 48.7％ and 90％ respectively.Conclusions Tg can be used as auxiliary diagnosis index of thyroid FTC.High preoperative Tg levels should be highly suspected the possibility of FTC.
