Expression of TK1 in benign and malignant tumors
10.3760/cma.j.issn.1674-6090.2017.05.007
- VernacularTitle:胸苷激酶1在良恶性乳腺肿瘤中的表达
- Author:
Kun FANG
1
;
Hong HOU
;
Qitang WANG
;
Cuiping WANG
;
Peng XU
;
Yue WAN
;
Qiang MU
Author Information
1. 266042,青岛大学附属中心医院乳腺中心
- Keywords:
TK1;
Breast cancer;
Breast fibroadenoma
- From:
Chinese Journal of Endocrine Surgery
2017;11(5):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of thymidine kinase 1 (TK1) in benign and malignant tumors.Methods From Jan.2013 to May.2015,180 female patients with breast diseases aging 16 to 79 years,including 112 cases of breast cancer (breast cancer group),and 68 cases of breast fibroadenoma (breast fibroadenoma group) were collected.The mean age of the patients was 47 years,with a median age of 43 years.We collected all the patients' fasting venous blood,detected the level of TK1,compared their differences of expression levels between patients with fibroadenoma and breast cancer,and the differences in serum TK1 levels in patients with different pathological characteristics.Results The level of TK1 in breast cancer patients was significantly higher than that in patients with fibroadenoma,and the difference was statistically significant (P＜0.01).In breast cancer group,the tumor size was not correlated with TK1 expression of (P＞0.05).The level of serum TK1 in patients with advanced TNM stage was higher than that in patients with early TNM stage (P=0.038).The level of serum TK1 in patients with advanced lymph node stage was higher than that in early lymph node stage (P=0.048).The level of TK1 in M1 patients was higher than that in M0 patients and the difference had statistical significance (P=0.018).Conclusion TK1,as a new marker of cell proliferation index,can accurately reflect the proliferation of tumor cells in human body,which can be used as an important index to monitor the degree of tumor proliferation and identify benign and malignant tumors.
