The value of intravoxel incoherent motion diffusion-weighted MRI in differentiating benign breast lesions from malignant lesions
10.3760/cma.j.issn.1674-6090.2017.05.003
- VernacularTitle:磁共振扩散加权成像IVIM模型在乳腺良恶性疾病鉴别中的价值
- Author:
Xiaojun ZHAO
1
;
Kun LIU
;
Xian ZHANG
;
Zhihan YAN
;
Zhongjie ZHOU
Author Information
1. 浙江省温州医科大学附属第二医院放射影像科
- Keywords:
Breast neoplasm;
Magnetic resonance imaging;
Diffusion-weighted imaging;
Intravoxel incoherent motion
- From:
Chinese Journal of Endocrine Surgery
2017;11(5):359-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic value of intravoxel incoherent motion (IVIM) diffusion-weighted MRI in differentiating benign from malignant breast lesions.Methods 50 female patients with lesions verified by pathology were included in this study,all of them underwent multi-b value (b=0-2000s/mm2) DWI scanning.Tissue diffusivity (D),pseudo-diffusivity (D*),perfusion fraction (f) and apparent diffusion coefficient (ADC) were acquired using IVIM model.The difference of these parameters in benign and malignant breast lesions was analyzed statistically.The diagnostic performance of these parameters was evaluated by ROC analysis.Results In benign lesions,D,D*,f and ADC value was (1.31±-0.47) ×10-3 mm2/s,(26.47±13.81) ×10-3 mm2/s,(17.35±3.78)％,(1.37±0.37)×10-3 mm2/s,respectively.In malignant lesions,D,D*,f and ADC value was(0.95±0.28)×10-3 mm2/s,(24.58±14.62)×10-3 mm2/s,(23.69±4.35)％,(1.03±0.14)×10-3 mm2/s,respectively.There were statistically significant differences between benign and malignant lesions in D,f and ADC value (t=3.203,-5.139,3.991,P＜0.05).There was no statisticaly significant difference in D* value (P＞0.05).ROC analysis showed that AUC of D value was 0.866,which was the highest one.AUC was increased to 0.934 by combining D with f value for diagnosis.Condusions The parameters acquired from IVIM model are useful to differentiate benign from malignant breast lesions.D value obtained from IVIM model may have relatively high sensitivity and specificity,D Combined with f value can obtain the best diagnostic performance.
