Research advances of endoplasmic reticulum stress in high glucose environment and its related ophthalmic diseases
10.3980/j.issn.1672-5123.2018.6.13
- VernacularTitle:高糖环境下内质网应激及其在眼科疾病的研究进展
- Author:
Jia-Jun LU
1
;
Min-Jie SHENG
;
Bing LI
Author Information
1. 同济大学医学院
- Keywords:
endoplasmic reticulum;
endoplasmic reticulum stress;
high glucose
- From:
International Eye Science
2018;18(6):1038-1042
- CountryChina
- Language:Chinese
-
Abstract:
· Endoplasmic reticulum (ER) is a place where it folds and synthesizes the proteins.ER stress was induced when a variety of physiological and pathological factors happened,under which the protein misfolding occurred,the unfolded protein accumulated and the calcium ion imbalanced in the ER.The ER of high-glucose environment can change the protein redox state and produce reactive oxygen species,which affects the ER channel function and chaperone protein buffer;meanwhile changes the balance of calcium ions;finally induces the formation of ER stress.More and more studies have confirmed that ER stress in high glucose environment can cause a variety of ophthalmic diseases.So we review the recent articles about ER stress of high glucose environment and its related ophthalmic diseases.
