Effect of microRNA - 155 on the pathogenesis of primary open angle glaucoma
10.3980/j.issn.1672-5123.2018.5.16
- VernacularTitle:microRNA-155在原发性开角型青光眼发病机制中的作用
- Author:
Ru-Fei YANG
1
;
Ying SU
;
Xin JIANG
;
Feng WANG
Author Information
1. 哈尔滨医科大学附属第一医院眼科分院
- Keywords:
microRNA - 155;
primary open angle glaucoma;
trabecular meshwork;
extracellular matrix
- From:
International Eye Science
2018;18(5):836-839
- CountryChina
- Language:Chinese
-
Abstract:
microRNA is specifically expressed in ocular tissues and plays a unique role in ocular tissues. microRNA- 155 regulates a variety of signaling pathways, affects the expression of the corresponding protein,then leads to the morphology and function abnormality of cells and tissue. The mechanism of primary open angle glaucoma is not yet clear. It is considered that the morphology and function abnormality of trabecular meshwork is the main cause of the increasing intraocular pressure. The effect of microRNA- 155 on primary open angle glaucoma can provide a new direction for the pathogenesis, diagnosis and treatment of primary open angle glaucoma.
