Analysis on the effect of anti-VEGF drugs on IOP, BCVA and mfERG changes in patients with idiopathic CNV
10.3980/j.issn.1672-5123.2018.2.39
- VernacularTitle:抗VEGF药物治疗特发性CNV的效果及对眼压、BCVA、mfERG的影响
- Author:
Peng-Ju JING
1
;
Wei-Hai LI
;
Jing CUI
;
Mei-Dong ZHU
Author Information
1. 郑州大学附属郑州中心医院眼科
- Keywords:
vascular endothelial growth factor;
choroidal neovascularization;
best corrected visual acuity;
intraocular pressure;
multifocal electroretinogram
- From:
International Eye Science
2018;18(2):353-355
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the efficacy of anti - vascular endothelial growth factor ( VEGF) drugs in the treatment of choroidal neovascularization ( CNV ) and its effects on intraocular pressure, best corrected visual acuity ( BCVA) and multifocal electroretinogram ( mfERG) .?METHODS:Totally 44 cases (44 eyes) of idiopathic CNV patients treated in our hospital from February 2015 to January 2017 were selected. All patients were treated with intravitreal injection of anti - VEGF. BCVA, intraocular pressure, mfERG and central retinal thickness ( CRT) were observed after treatment.?RESULTS:At 1 and 3mo after treatment, BCVA and CRT were significantly improved than those before treatment (P<0. 05). At 3mo after treatment BCVA and CRT were 0. 60±0. 15 and 278. 43±40. 10μm, both significantly lower than that in 1mo after treatment (P<0. 05). There was no significant change in intraocular pressure at 1 or 3mo after treatment than before treatment (P>0. 05). At 1 and 3mo after treatment, amplitudes of Ring1, Ring2 and Ring4 NI-P1 were higher than those before treatment (P<0. 05);at 3mo after treatment, the amplitude of Ring3 NI-P1 were higher than those before and 1mo after treatment (P<0. 05);at 1mo after treatment, the amplitude of Ring5 NI- P1 were higher than those before and 3mo after treatment (P<0. 05). The amplitude of Ring6 NI-P1 did not change significantly at 1 and 3mo after treatment, compared with before treatment (P>0. 05).?CONCLUSION: Anti-VEGF drugs are effective in the treatment of idiopathic CNV, which can improve vision and macular retinal function, decrease the retinal thickness, and do not affect the intraocular pressure.
